• 专利附录
  • 专利说明
  • 权利要求
  • 类似技术
  • 同族专利
  • 引用文献
  • 法律状态
  • 优先权
    • 专利摘要:
    Aminogruppenmodifizierte Kieselgele eignen sich als Trä­germaterialien für Technetium-99m-Generatoren, da sie Kupfer(II)-Ionen gut festhalten und somit ein kupferfreies Eluat ergeben.
    公开号:SU1471959A3
    申请号:SU864028062
    申请日:1986-09-01
    公开日:1989-04-07
    发明作者:Кульманн Людвиг；Пюттер Дитрих
    申请人:Хехст Аг (Фирма)；
    IPC主号:
    专利说明:

    . The invention relates to nuclear physics and can be used for the preparation of technetium-99M solutions for use in nuclear medicine diagnostics.
    The aim of the invention is to reduce the amount of molybdenum-99 in the eluate.
    FIG. Figures 1 and 2 show the relative position of the layers of alumina and silica gel modified with amine groups.
    The drawing shows: case 1 of the generator column, layer 2 of alumina, layer 3 of silica gel modified with amino groups, layer 4 of alumina with copper (II) i adsorbed on it
    Modified amino groups of silica gel may contain primary, secondary or tertiary amino groups,
    As magnesium silicates, natural materials can be used, such as phosphite, enetatite, serpentine, serpentine asbestos, talc, anti-burning, as well as ortho, di- or polysilicate magnesium.
    Example. 105 mg of silica gel is loaded into a glass column and 1.0 g of alumina is poured over it. The column is then precipitated daily, during the working day, and elution is carried out with physiological saline solution containing 20 µg / ml CuCl. Before adding copper chloride
    (Ii) the salt solution is sterilized in an autoclave.
    The yield of tenchenez -99M is 80-95%, the content of Mo-99 in the zljuat is less than 1 rpm.
    F o rmula of the invention
    .one. Techneti-99M generator, made in the form of a generator column,
    containing a layer of aluminum oxide with molybdenum-99 adsorbed in it on a carrier, and containing as eluent a solution including copper (II), which differs from
    By the fact that, in order to reduce the amount of molybdenum-99 in the eluate, it contains in the lower part of the generator column a layer of amino group-modified silica gel.
    . 2. The generator according to claim 1, of tl ischach y i and. so that magnesium silicate is introduced into at least one of the layers in the column.
    3. The generator PP. 1 and 2, about t and h and y and i that contains located in the form of the upper layer in the generator column alumina with copper (II) deposited on it.
    I
    us.1
    权利要求:
    Claims (3)
    [1]
    Claim
    1. The technetium-99M generator, made in the form of a generator column containing an alumina layer with molybdenum-99 adsorbed on it on a carrier, and containing as solution an eluent comprising copper (II), characterized in that, in order to reduce the amount molybdenum-99 in the eluate, it contains in the lower part of the generator column a layer of amino-modified silica gel.
    •
    [2]
    2. The generator by π. 1, on the left. with the fact that magnesium silicate is introduced into at least one of the layers in the column.
    [3]
    3. The generator according to paragraphs. 1 and 2, characterized in that it contains aluminum oxide deposited on it in the form of an upper layer in the generator column with copper (II) deposited on it.
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    同族专利:
    公开号 | 公开日
    BE905368A|1987-03-02|
    US4837110A|1989-06-06|
    EP0213589A3|1988-03-16|
    PT83290B|1993-04-30|
    CA1276448C|1990-11-20|
    IE862345L|1987-03-03|
    EP0213589A2|1987-03-11|
    DE3531355C2|1992-06-11|
    DK417786A|1987-03-04|
    DK417786D0|1986-09-02|
    DE3531355A1|1987-03-12|
    AT63013T|1991-05-15|
    ZA866644B|1987-04-29|
    EP0213589B1|1991-04-24|
    PT83290A|1986-10-01|
    JPS6271900A|1987-04-02|
    IE59192B1|1994-01-26|
    GR862237B|1986-12-31|
    DE3678880D1|1991-05-29|
    ES2003343A6|1988-11-01|
    引用文献:
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    RU2443030C2|2010-02-03|2012-02-20|Федеральное государственное унитарное предприятие "Ордена Трудового Красного Знамени научно-исследовательский физико-химический институт им. Л.Я. Карпова" |TECHNETIUM-99m GENERATOR WITH SULFO-CARBOXYLATED CATION-EXCHANGING PROTECTIVE LAYER AND THE METHOD OF ITS PRODUCTION|US3369121A|1966-04-06|1968-02-13|Squibb & Sons Inc|Radioactive package and container therefor|
    NL6607699A|1966-06-03|1967-12-04|
    US3664964A|1968-07-03|1972-05-23|Squibb & Sons Inc|Eluent for radioisotopes|
    US3755161A|1970-02-05|1973-08-28|Osaka Soda Co Ltd|Treatment process for removal of metals and treating agent therefor|
    CA955035A|1970-02-05|1974-09-24|Osaka Soda Co.|Treatment process for removal of metals and treating agent therefor|
    US3740558A|1971-02-17|1973-06-19|Dainabot Radioisotope Labor Lt|Radioactive isotope generator of short-lived nuclides|
    NL7503293A|1975-03-19|1976-09-21|Leuven Res & Dev Vzw|METHOD OF REMOVING METALS FROM SOLUTION.|
    US4167481A|1975-03-19|1979-09-11|Leuven Research & Development Vzw|Process for the removal of metals from solution|
    US4158700A|1976-03-08|1979-06-19|Karageozian Hampar L|Method of producing radioactive technetium-99M|
    DE2906439A1|1979-02-20|1980-09-04|Hoechst Ag|METHOD FOR SEPARATING TECHNETIUM-99M FROM MOLYBAEN-99|
    CA1169773A|1979-04-17|1984-06-26|Karel J. Panek|Preparation and use of asu195m xxau-containingliquid|
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    法律状态:
    优先权:
    申请号 | 申请日 | 专利标题
    DE3531355A|DE3531355C2|1985-09-03|1985-09-03|
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